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Patients with liver disease frequently take lactulose, rifaximin, beta-blockers (for portal hypertension prophylaxis), diuretics, and sometimes direct-acting antivirals for hepatitis C
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Glutathione reductase (GR), an NADPH-dependent enzyme, continuously regenerates reduced glutathione (GSH) from its oxidized form (GSSG), thereby maintaining the intracellular reducing environment required for effective antioxidant defense, proper enzymatic activity, and redox-dependent signaling pathways [36]
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