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Tirzepatide is the first dual agonist which has been approved for chronic weight management, but numerous other dual and/or triple agonists (cagrisema, retatrutide, mazdutide and survodutide) are also in phase 3 trials as potential treatments for obesity and its metabolic complications
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For detailed comparison, see our complete semaglutide vs tirzepatide guide
GLP-1RAs are essential for preventing fractures in people with T2DM because they greatly increase bone mass, trabecular and cortical architecture, and total bone strength
Buchwald et al., Bariatric surgery A systematic review and Meta-analysis
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