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Mounjaro uses tirzepatide to target both GIP and GLP-1 receptors

Improvement goals include: Kidney Disease: although as rare as 1 percent, Semaglutide may cause kidney injury leading to kidney failure requiring hemodialysis

PMID 27844051

Clinical trials suggest that patients who achieve at least 5% body weight loss by months three to four are likely to be long-term responders

Tirzepatide adds activation of the GIP receptor as well, which in trials has shown greater effects on weight loss and metabolic improvements, but also demands careful dosing to manage side effects

It induces lipolysis (fat breakdown) in adipose tissue, increasing the production of free fatty acids and ketone bodies