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Gradual transition: When switching, take the new medication after at least 7 days

The response was most pronounced in patients with darker baseline skin tones (phototypes IV-VI)

Patients on brand-name medications pay a separate $25/mo treatment plan fee on top of the medication cost, but no monthly charge is attached to compounded prescriptions

As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]

Hypoglycemia-related symptoms tend to emerge 2-4 hours after eating, particularly after high-carbohydrate meals that trigger an exaggerated insulin response

In summary, administration of melanotan I is restricted to clinicians and researchers