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68-week bone density data showed no significant changes from baseline

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NAD(+) analog reveals PARP-1 substrate-blocking mechanism and allosteric communication [PMID: 29487285] Laboratory literature summary: NAD(+) analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

Phase I: Feasibility Phase I is a small, fixed-scope award to prove technical merit and feasibility