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6.6% of patients discontinue tirzepatide due to adverse effects during its phase 3 trial [47]

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31715-21, (2002) (PubMed)

GSH depletion in the brain is a common finding in patients with neurodegenerative diseases

In our clinical practice, a baseline brain MRI is offered to patients with large CMN overlying the lower spine which may prompt referral to neurology or ongoing monitoring, although some parents choose to forego imaging given the limited available interventions

As of early 2026, 503A compounding pharmacies may compound semaglutide under specific conditions related to drug shortage status and patient-specific prescriptions