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The consequences of this assumption are outlined in the discussion

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In this theory, principal drug represents a basic component of the prescription, and its main role is to target the cause of the disease or the main syndrome

The more inhibition of bile acid synthesis could also partly account for the more accumulation of cholesterol in the liver in mice carrying gut microbiota Desulfovibrionale

Insufficient autophagy inhibits Nrf2-mediated antioxidant defenses, promoting iron deposition and LPO, leading to ferroptosis (Peng et al., 2022)