Rudolph Eberwein, MD, agrees
TRIUMPH-1's prespecified 104-week extension (BMI 35 subgroup) showed average weight loss reaching 30.3% higher than the 28.3% at week 80
Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges
The question is whether adding AOD 9604 justifies the additional cost, injection frequency, and complexity
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