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In humans, the SHMT enzyme exists in two isoforms, with the cSHMT gene encoding the cytosolic/nuclear enzyme (cSHMT) and the mSHMT gene encoding a mitochondrial SHMT enzyme

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However, their high cytotoxicity possibly compromising epithelial integrity greatly limited their clinical translation

Liposomal delivery is an innovative approach and is widely regarded as the most successful substance delivery system to date

Researchers should note minor and transient side effects that have been anecdotally reported: Headaches Drowsiness

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