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[15] [14] While mild gastrointestinal symptoms are common and often transient with GLP-1 therapy, certain warning signs warrant prompt medical evaluation

The absorption process is fundamentally different

N Am J Med Sci

Reductions in blood glucose together with increased energy expenditure (EE) and decreased food intake, resulting in loss of fat mass, were reported for a different dualAG (chimeric GLP-1/GCG peptide) following one-month treatment 9 and for BI456906 dualAG in DIO mice treated during 4 weeks and in phase 1 and 2 trials 10,11

They are not FDA-approved drugs, but they are legally prescribed as compounded medications under physician supervision

Concomitant use of weight-promoting medications, such as insulin or sulfonylureas, may further blunt the weight loss effects of GLP-1 RAs [45]