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While these medications primarily reduce fat body mass (FBM), loss of lean body mass (LBM) can also occur, raising concerns about muscle loss in susceptible populations, such as frail individuals and older adults
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1 H MRS in the muscle allows detection of multiple metabolites, of which creatine, acetyl-carnitine, carnosine and intramyocellular lipids (IMCL) have been shown to be useful biomarkers of muscle metabolism [23]
The net price after rebates for branded Humira remained competitive with biosimilar list prices, and many PBMs found it financially rational to maintain Humira preferred status
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