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Cold intolerance is not listed among the common adverse effects in the Summary of Product Characteristics for semaglutide (Wegovy) or liraglutide (Saxenda), which typically include gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation), injection site reactions, and headache
Ringseis R, Keller J, Eder K
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Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach of rats
Nonetheless, these transient interactions are clearly essential for receptor activation, with mutation of the majority of residues within the TMD cavity decreasing exendin-P5 efficacy, but not affinity
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