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Topical and cosmetic application in humans is the best-supported use, with controlled dermatological studies showing measurable effects on skin parameters Grade B

Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury

For example, altered levels of short-chain ACs, including C2 and C3, have been observed in coronary artery disease and diabetes [6, 55]

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2, along with the corresponding changes in the appearance of the skin with aging

You could taper by 1 mg at a time rather than 2.5 mg, creating an even more gradual transition