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In vitro studies have found that inhibiting the transcriptional activity of Nrf2 can reduce the synthesis of glutathione, thereby causing the apoptosis of IDH1 mutant cancer cells

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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AA: amino acid AOPP: advanced oxidized protein products ASR: absolute synthesis rate FSR: fractional synthesis rate GSH: glutathione ROS: reactive oxygen species References Richmond S, Goldsmith JP 2006 Air or 100% oxygen in neonatal resuscitation

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In adults, the main detoxification pathway of paracetamol is glucuronidation to the non-toxic metabolite glucuronide, while in the foetus the main metabolic pathway initially involves sulphation

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