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The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: Lessons learned from its deficiency
It also impacts cellular signalling in brain tissue, with potential applications in targeting neurodegenerative diseases and alleviating brain fog
An analysis of the FUS interactome by mass spectrometry showed that mutant FUS has an increased association with enzymes involved in glucose metabolism, compared to wild-type FUS [180]
While research on neurodegenerative diseases has advanced significantly, with increasing insights from cell lines and murine animal models highlighting the bidirectional link between energy metabolism and brain inflammatory responses, the specificity of human specimens is limited to postmortem brain tissues
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