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The clinical picture is very variable, depending on the site of occurrence and the degree of involvement of the upper and lower motor neurons (Luna et al
Monotherapy protocols are commonly initiated at 0.6 mg per week and escalated to a maximum studied dose of 4.5 mg as tolerated
doi: 10.1038/ni.2112 180 NavasardyanIBonavidaB
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Statistics All values are presented as means SE
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