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The beneficial effects of SGLT2 inhibitors on metabolic outcomes (BP control, body weight) were also shown in a meta-analysis of RCTs in non-diabetic individuals [96]

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The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

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