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This degradation by DPP-4 is evaded because most GLP-1 analogues contain an amino acid substitution at the N-terminal end

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[6] KPV KPV in Gut Inflammation Control The study concluded that KPV reduces inflammation by getting into cells through the PepT1 transporter, where it slows down overactive immune and intestinal cell signals (NF-B and MAPK), which lowers the production of molecules that cause inflammation

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Insulin-Like Growth Factors: Actions on Skeletal and Metabolic Systems