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Published in the NEJM in March 2021, the STEP 1 trial randomized adults with obesity or overweight plus 1 weight-related condition who did not have diabetes to semaglutide 2.4 mg or placebo for 68 weeks

Originally approved for the treatment of type 2 diabetes, Semaglutide works by mimicking the effects of GLP-1, thereby improving blood sugar control in diabetic patients

Zhou J, Montrose-Rafizadeh C, Janczewski AM, Pineyro MA, Sollott SJ, Wang Y, and Egan JM

Between 2019 and 2023, there was a 400% increase in prescriptions for them