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Preclinical safety data In mouse studies, 5-amino-1mq was well-tolerated even at doses several times higher than those producing metabolic effects
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Weight loss stalls despite good adherence
Traditional obesity intervention strategies (e.g., dietary control, exercise, conventional weightloss drugs) are often limited by slow onset, obvious side effects, and high rebound rates, and can hardly fundamentally reverse the abnormal metabolic phenotype of adipose tissue
