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It is believed that up to 90% of vegans and vegetarians are deficient in B12 (R, Se and T, 2014), and therefore recommended that they should use supplements to ensure their continued health
This mechanism becomes clinically important when using high-dose oral supplements (typically 1000 micrograms or more), as it can provide adequate absorption even when the intrinsic factor pathway is impaired
It means that anyone using it should understand they are in largely uncharted territory and proceed with appropriate caution and monitoring
