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2a and Extended Data Figs

Accession #2606040191, reported 06/07/2026

This condition can cause: Severe abdominal pain Inability to pass gas or bowel movements Swollen abdomen Intestinal blockage is a medical emergency and requires immediate attention to prevent more serious complications

Discontinuation timing was identified through prescription records, and causes for discontinuation were adjudicated based on clinician documentation and diagnostic coding within the electronic medical record

We then asked whether depletion of SMARCAL1, ZRANB3 and HLTF, motor proteins that promote fork reversal, would alleviate fork attrition in mutant cells (Fig