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This is a concern for individuals that are vegan or vegetarian as they may be at a higher risk for deficiency of vitamin B12

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Once oxidized during ROS detoxification (most notably through glutathione peroxidasemediated reduction of hydrogen peroxide), glutathione must be regenerated from its oxidized form (GSSG) by glutathione reductase, a process dependent on a continuous supply of NADPH from the pentose phosphate pathway (3)