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[1] Diabetes as a Multi-Organ Signaling Disorder Taken together, diabetes is best understood not simply as a lack of insulin, but as a breakdown in insulin signaling across multiple organs

The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions

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ProLuCID data was filtered through DTASelect (version 2.0) to achieve a peptide false-positive rate below 1%

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