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Nature and Science of Sleep, 10, 421-430

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Table 2 Changes between baseline and 12 months after GLP-1 receptor agonist initiation

A 2025 network meta-analysis ranked nausea risk as follows: orforglipron (highest, relative risk 4.77), liraglutide (3.09), semaglutide (2.94), tirzepatide (2.89), exenatide (2.66), and cagrilintide (2.29)