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Most of that research is preclinical rather than large human trials

One of the best-supported areas is wound healing

Scientific Reports, 12 (1), 1-9

In RA, CCL2, CCL3, CCL4, CCL5, CCL7, CCR1, CCR2, CCR5-7, CCR9, and CCR10 induce monocytes to enter the joint synovial

Simple timing framework Baseline Discuss baseline labs before starting, especially with autoimmune disease, infection risk, cancer history, liver or kidney issues, anticoagulant use, or a recent major injury

Previous bariatric surgery Patients with any history of gastric bypass, sleeve gastrectomy, or other bariatric procedures require lifelong b12 monitoring and supplementation