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This study aims to address this knowledge gap by elucidating the specific mechanisms through which TA alleviates oxidative damage, modulates ER stress, and preserves hepatocyte integrity
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Presented for research literature review only Yan A et al
Proc Natl Acad Sci 2008;105:18782-7
The model is also consistent with published results that show that female mice are less susceptible than males to hepatotoxicity due to acetaminophen overdose and suggests that this might also be true for humans, though the human epidemiological data are contradictory