Your body produces them in bursts, they deliver a signal to nearby cells, and then enzymes (particularly DPP-4, neprilysin, and various endopeptidases) break them down within minutes
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Endocrinology 123:20092013 Overton HA, Fyfe MC, Reynet C (2008) GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity