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Cell 124 , 783801 (2006)

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Several factors explain the lack of approval: insufficient clinical trials (no completed Phase 3 trials for most indications), safety concerns (FDA has identified specific adverse events), commercial considerations (patent status affects development investment), regulatory pathway (approval requires specific, rigorous documentation), and competition (Tesamorelin already approved for related indication)

References Barca, D

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Increased glutathione contributes to stress tolerance and global translational changes in Arabidopsis