(PubMed) Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B
High levels of saturated free fatty acids can cause ER stress that activates the UPR pathway by various mechanisms, such as inhibition of the enzyme that mobilizes ER Ca 2+ (i.e., ER Ca 2+ ATPase), activation of IP3 receptors, and/or directly impairing ER homeostasis (241)
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