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These patients also exhibit deficits in auditory sensory processing that manifests as impaired mismatch negativity (MMN), which is an auditory evoked potential (AEP) component related to NMDA receptor function

Moreover, the data used for this model did not extend beyond 52 weeks, necessitating extrapolation

Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Tirz initiation Weeks 1-4 Tirzepatide 2.5 mg/week Cagrilintide Not started Notes Confirm tirzepatide GI tolerance first

As your heat tolerance builds, aim for 1520 minutes at 160F180F