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Compared to the first-generation GLP-1R agonist, tirzepatide has three critical improvements: first, many residues in peptide backbone are changed to obtain GIPR-activating activity
As a result, scientists do not yet have large studies directly evaluating how semaglutide affects sperm production
This is information, not legal or medical advice
In the case of tirzepatide, a recent meta-analysis of the SURPASS clinical trial programme did not identify any increased risk of EWDR (Popovic et al, 2024)
Muscle mass decreases at 3 to 8% per decade after 30
Most before/after posts attribute everything to the drug
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