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Proglucagon is subsequently processed by the prohormone convertases 1, 2 and 3 50 to produce, among other products, the 29-amino-acid-long GCG (in human, positions 5381, PSCK2) and the 30-amino-acid-long GLP-1 736 (positions 98127, PSCK1), which are the focus of this work
MERCS also integrates sensors of the unfolded protein response (UPR), including PERK and IRE1 (Verfaillie et al., 2012)
GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone produced in the intestines that regulates blood sugar and appetite but lasts only 1-2 minutes in the body
What was this Lixisenatide study all about
People with type 2 diabetes tend to lose less weight on GLP-1 medications, likely because of differences in insulin resistance and starting weight 3,4
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