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Among these, sesquiterpene farnesol, which is present in many essential oils, has demonstrated the ability to potentiate the activity of beta-lactam antibiotics against Burkholderia pseudomallei
Perturbation of this axis, either through direct GPX4 inhibition or GSH depletion via impaired cystine import (for example, via system Xc inhibition), markedly sensitizes cells to ferroptotic death (1,16)
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