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The current understanding points to a potential biphasic pattern in GLP-1 RA studies, where any observed early worsening may be related to rapid glycemic improvement rather than direct retinal toxicity, particularly in patients with pre-existing retinopathy, poor glycemic control, and those undergoing HbA1c reduction 47

r = 0.97, P 25% weight loss were slightly younger (mean age 56.2 versus 58.2 years), more likely to be female (80.9% versus 61.8%), and had higher baseline BMI (36.9 versus 35.2 kg/m 2 ) but lower hemoglobin A1c levels (6.2% versus 6.6%)

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Many people ask whether Semaglutide causes weight loss by creating an unpleasant feeling of starvationbut the science tells a different story