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This is among the more speculative areas of research
Recreational Nitrous Oxide Causing Deep Vein Thrombosis and Subacute Combined Degeneration: Whip It Real Good
Without adequate B12, homocysteine levels rise, and elevated homocysteine is neurotoxic, potentially causing direct damage to nerve cells and blood vessels that supply nerves
Newborn Screening for Vitamin B12 Deficiency in Germany-Strategies, Results, and Public Health Implications. The Journal of pediatrics vol
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11 Its also important to note that taking B12 in combination with vitamin B6 and folate (rather than alone) is shown to be most effective for regulating homocysteine levels for some patients and preventing the combined risk of stroke, myocardial infarction (heart attack), and damage to heart cells
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