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As a proof of concept, PLGA nanoparticles encapsulated with DDA-GSH-AuNCs were dosed to cultured cells (MCF-7) to evaluate the ability to visualize their uptake using confocal fluorescence microscopy

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In vitro studies using HGL5 cells showed melatonin reduced oxidative stress markers, improved mitochondrial function, restored expression of glycolysis and TCA cycle-related genes and modulated cuproptosis and ferroptosis-related gene expression

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