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Prospective, randomized, double-blind, parallel-group, comparative effectiveness clinical trial comparing a powder vehicle compound of vitamin D with an oil vehicle compound in adults with cystic fibrosis

Clinical trials are necessary to determine the appropriate dosage for humans

Promotes healthy blood vessel formation and function, supporting cardiovascular health and optimal tissue perfusion throughout the body

Heightened inflammation: Dysregulated NF-kB pathways promote pro-inflammatory cytokines

Participants maintained their weight loss at 6-month follow-up, suggesting the metabolic benefits persist beyond active treatment

The 50100mg daily dose range was derived from rodent models where 10mg/kg bodyweight produced measurable NNMT suppression without toxicity across 12-week administration periods