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The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity), completed in 2023 with over 17,600 participants, demonstrated a 20% reduction in major adverse cardiovascular events in patients with established cardiovascular disease and overweight or obesity but without diabetes
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Pellizzari Tregno F, Sau A, Pezzola S, Geroni C, Lapenta C, Spada M et al
Not managing the conversation effectively may now prove to have been a strategic oversight given the reports of plateauing efficacy, which has payers and healthcare systems questioning the long-term cost-effectiveness of GLP-1s for either weight loss or type 2 diabetes, and tightening access
Analysis of genetic inheritance in a family quartet by whole-genome sequencing
