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Demonstrating a direct, weight-independent hepatic effectparticularly mediated through LSECsadds an entirely new layer of biological plausibility and therapeutic relevance

Common injection sites include the abdomen, upper thigh, or upper arm

FIGURE 1 The mechanism of GLP-1 RAs, however, is now understood to extend far beyond glucose control, offering powerful dual central and peripheral action

These protective effects were consistent regardless of whether the patients had diabetes or obesity

Spark Therapeutics, BioMarin, Takeda, and UniQure have all filed extensive patent portfolios in this space