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Moreover, a comparison of the number of animals with unhealed defects (all controls) or healed defects (complete bony continuity across the defect site) showed that besides pentadecapeptide intramuscular application for 14 days (i.e., local application of bone marrow or autologous cortical graft), also following other pentadecapeptide BPC-157 regimens (local application, or intermittent intramuscular administration), the number of animals with healed defect was increased
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10.1007/s12035-014-8995-z Mol
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However, when Cys 129 residue of PTPN22 is mutated, the disulfide bond cannot form and the enzyme is exposed by oxidation, resulting in inactivation (93)
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