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A normal dose is up to 1,000 milligrams (mg) over a four-to-six-hour period and a total of no more than 4,000 mg in a day

Statistical significance was determined by two-tailed unpaired t -test

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For a 2.4-milligram pen, 25 units equals 0.75 milligrams, while the same 25-unit measurement from a higher-concentration pen would deliver a different milligram amount