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Karena itu, menjaga kadar glutathione tetap optimal sangat penting untuk melindungi sel dari stres oksidatif yang dapat memicu perkembangan penyakit ini

Drinking water alongside alcohol helps the body stay hydrated, which in turn supports all metabolic functions

DNA Constructs As shown in Figure S4B in Supplementary Material, pcDNA3.1-Flag-GSTP, pcDNA3.1-Flag-HMGB1, pcDNA3.1-Flag-GSTM, six GSTP phosphorylation mutants including pcDNA3.1-Flag-GSTP-S42A (in which serine-42 was mutated to alanine, a S42 non-phosphorylatable mutant), pcDNA3.1-Flag-GSTP-S42D (in which serine-42 was mutated to aspartate, a Ser42 constant-phosphomimetic mutant), pcDNA3.1-Flag-GSTP-S184A (in which serine-184 was mutated to alanine, a Ser184 non-phosphorylatable mutant), pcDNA3.1-Flag-GSTP-S184D (in which serine-184 was mutated to aspartate, a Ser184 constant-phosphomimetic mutant), pcDNA3.1-Flag-GSTP-Y198F (in which tyrosine-198 was mutated to phenylalanine, a Tyr198 non-phosphorylatable mutant) and pcDNA3.1-Flag-GSTP-Y198D (in which tyrosine-198 was mutated to aspartate, a Tyr198 constant-phosphomimetic mutant), pET28a-HMGB1, pET28a-GSTP(WT), pET28a-GSTP(S184A), pET28a-GSTP(S184D) were constructed by using molecular cloning technology

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Our findings demonstrated that GSH inhibition leads to synthetic lethality in VRK2-deficient PC cells, which exhibits impaired expression of SLC7A11 at PM level

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