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The auditory brainstem response (ABR) test results of ATG5-knockout mice at 4 or 8 postnatal weeks showed that at the frequencies of 2, 4, 16, and 32 kHz, the heterozygous mice displayed normal hearing whereas the homozygotes showed marked hearing loss
This makes perfect sense as erythrocytes take up large amounts of sphingosine and detoxify this sphingolipid by enzymatic conversion to sphingosine-1-phosphate by sphingosine kinase [124]
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