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A C20 fatty di-acid moiety attached via a Glu2AEEA linker enables reversible serum albumin binding and extends the circulating half-life to approximately six days, supporting once-weekly research dosing protocols comparable to those used for tirzepatide and semaglutide

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However, it is essential to validate the clinical significance and sustainability of the possible benefits in diverse population groups who may not necessarily aim for weight loss through carefully designed and sufficiently powered studies

References Jin X, Qiu T, Li L, Yu R, Chen X, Li C, et al

So far, no trials have been published that compare different dual- or triple-receptor agonists with each other

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