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When re-escalation is attempted after 4 to 8 weeks, many patients tolerate the higher dose on the second attempt
This provides evidence of the continued impact of unhealed traumatic events on the potential development of central pain hypersensitivity
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Research shows this gradual increase maximizes weight loss while minimizing discomfort
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A molecular readout (actin binding), a cellular readout (migration), and a clinical outcome (a healed tendon) are three different evidence tiers
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