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However, it is well known that in vivo , NDDs often involve heterogenous representations across multiple brain regions

Without NAD, your cells won't be able to metabolize carbohydrates, fats and amino acids

In contrast, FOXO4-DRI leverages the elevated expression of FOXO4 and P53 in senescent cells by specifically blocking the interaction between FOXO4 and P53 to promote apoptosis via the P53 signaling pathway (Tao et al., 2016

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