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Randomised controlled trials involving GLP-1RA have not detected suicidality signals, but these studies were underpowered to detect rare events such as SIS, and they selectively exclude individuals with psychiatric comorbidity [23,24,25,26], which are prevalent in daily practice
Clin Endocrinol (Oxf) 57: 577-585 Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, et al
These tools help detect potential safety signals but do not account for confounding variables such as baseline patient characteristics, comorbidities, or concomitant medication use
Store at room temperature (68F to 77F or 20C to 25C), with permitted excursions between 59F to 86F (15C to 30C), in a dry location, never in bathrooms or near sinks
Conclusions and Future Perspectives The collective evidence positions incretin receptor agonists as a unique class of drugs with multi-organ anti-fibrotic potential, now extending to fibro-inflammatory diseases like osteoarthritis
