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Dependent on the TREM2-APOE pathway, microglia lose the expression of genes encoding homeostatic molecular profile (P2ry12, Tmem119, Csf1r, Hexb, Mertk, Cx3cr1) and upregulate the expression of inflammatory genes (Apoe, Itgax, Ccl2, Clec7a, Axl)

The lactate-driven metabolic reprogramming enhances mitochondrial oxidative phosphorylation and sustains Foxp3 expression, thereby reinforcing the immunosuppressive phenotype of Tregs

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doi: 10.3389/fmolb.2015.00050 Received 19 December 2014 Accepted 19 August 2015 Published 03 September 2015 Volume 2 - 2015 Edited by Laszlo Otvos, OLPE LLC, USA Reviewed by Anja Kunze, University of California, Los Angeles, USA