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If fatigue persists beyond the initial adjustment period or significantly impacts daily functioning, further evaluation is warranted to identify underlying causes
As initial treatment D-Penicillamin (DPA) was chosen in 25 patients, Trientine Dihydrochloride (TRI) in 5 patients, Zinc in two patients and combination of TRI and Zinc as well as DPA and Zinc in one patient respectively
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The primary histological endpoint of the month 18 interim analysis (intent-to-treat [ITT], n=931) was improvement in fibrosis 1 stage with no worsening of NASH using the NASH Clinical Research Network criteria